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This left doctors with limited evidence about how the drugs affect older adults

Individuals with certain medical conditions or who take certain medications should consult with a healthcare provider prior to initiating

This is particularly concerning given that people with obesity-related comorbidities may reap the greatest benefit from treatment. Thomsen noted the irony that patients most likely to benefit from sustained treatment were often those most likely to abandon it due to side effects or other health complications

2012 Feb;177(2):392-401

[9] This weight reduction can further improve insulin sensitivity and restore menstrual regularity in many women with PCOS